Factors such as the technology of the device, the quality of the formulation, the patient ability to properly use the device, can all have an impact on the quality and quantity of emitted doses.

The first use of pullulan was reported in 1938. Commercial production of pullulan began in Japan in 1976. 

Vcaps® capsules are made from HPMC - hydroxypropylmethylcellulose - a cellulosic material derived from pine trees.

Research, conducted by the Natural Marketing Institute in 2013 for Capsugel, showed that  38% of consumers in the US prefer capsules that are plant-based.

An increasing number of active compounds in pipelines today have properties that require functional formulation to enable exposure and efficacy. Despite many new technology choices, it is often difficult to match the right drug-delivery technology to a given molecule and problem statement.